REVIEW: PROCESS OF FLUID BED GRANULATOR PARAMETERS AT THE TIME OF SCALE UP IN GRANUL PRODUCTION
نویسندگان
چکیده
Scaling up is one of the difficulties faced by production process pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding crucial variables that affect final product's specifications will aid choosing appropriate upgrade settings. Fluidized-bed granulation most frequently used techniques to increase The complex fluidized bed influenced several factors. important were intake air temperature and humidity, concentration binder solution, spray rate, atomizing pressure, flow rate. Numerous investigations have examined effects large-scale fluid granulation. An improved technology was employed based on relative droplet moisture content powder after spraying cycle. These values are comparable, demonstrating procedure can be enhanced considering only size. Keywords: granulation, parameters,
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ژورنال
عنوان ژورنال: Medical sains : jurnal ilmiah kefarmasian
سال: 2023
ISSN: ['2548-2114']
DOI: https://doi.org/10.37874/ms.v8i3.836